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2014年9月9日(担当:鳥井) Villa JC et al. Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer. Cell Rep. 8:1077-1092.2014. |
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2014年9月2日(担当:中島) Hubbi MEet al. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. Proc Natl Acad Sci U S A. 111:E3325-E3334. 2014. |
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2014年8月19日(担当:堤) Kilic Eren M et al. The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced Senescence. PLoS One. 9:e101064. 2014. |
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2014年8月12日(担当:片桐) Sinkevicius KW et al. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proc Natl Acad Sci U S A. 111:10299-10304. 2014 |
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2014年7月29日(担当:井上) Ingolia NT et al. Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling. Science. 324:218-223. 2009. |
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2014年7月22日(担当:後藤) Chaturvedi P et al. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proc Natl Acad Sci U S A. 111:E2120-E2029. 2014. |
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2014年7月8日(担当:小林) Norman MZ et al. PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med. 211:781-790. 2014 |
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2014年7月1日(担当:鳥井) Ramasamy SK et al. Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature. 507:376-380. 2014. |
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2014年6月24日(担当:中島) Ferrer CM et al. O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway. Mol Cell. 54:820-831. 2014. |
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2014年6月10日(担当:堤) Taniguchi CM et al. PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2. Sci Transl Med. 6(236): 236ra64. 2014. |
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2014年6月3日(担当:片桐) Faubert B et al. Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α. Proc Natl Acad Sci U S A. 111:2554-2559. 2014. |
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2014年5月20日(担当:井上) Ward A and Hudson JW. p53-Dependent and Cell Specific Epigenetic Regulation of the Polo-like kinases under Oxidative Stress. PLoS One.9:e87918. 2014. |
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2014年5月13日(担当:後藤) Finger EC et al. CTGF is a therapeutic target for metastatic melanoma. Oncogene. 33:1093-1100. 2014. |
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2014年4月22日(担当:小林) Joshi HP et al. Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis. Proc Natl Acad Sci U S A.111:5331-5336. 2014. |
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2014年4月15日(担当:鳥井) Spencer JA et al. Directmeasurementoflocaloxygenconcentrationin the bone marrow of live animals. Nature. 508:269-273. 2014. |
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2014年4月1日(担当:中島) Chen X et al. XBP1 promotes triple-negative breast cancer by controlling the HIF1a pathway. Nature. 508:103-107. 2014. |
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2014年3月25日(担当:堤) Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response. Proc Natl Acad Sci U S A. 111:2560-2565. 2014. |
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2014年3月18日(担当:片桐) Sun RC and Denko NC. Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth. Cell Metab. 19:285-292. 2014. |
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2014年3月11日(担当:井上) Xie CM et al. Cardiac glycosides block cancer growth through HIF-1α- and NF-κB-mediated Plk1. Carcinogenesis. 34:1870-1880. 2013. |
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2014年2月25日(担当:後藤) Wang HJ et al. JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism. Proc Natl Acad Sci U S A. 111:279-284. 2014. |
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2014年2月4日(担当:小林) Barriga et al. The hypoxia factor Hif-1alpha controls neural crest chemotaxis and epithelial to mesenchymal transition. J Cell Biol. 201:759-776. 2013. |
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2014年1月28日(担当:原田) Yang et al. Reciprocal regulation of HIF-1alpha and LincRNA-p21 modulates the Warburg effect. Molecular Cell. 53:88-100. 2014. |
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2014年1月21日(担当:鳥井) Cowburn AS et al. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci U S A. 110:17570-17575. 2013. |
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2014年1月14日(担当:子安) Blandino G et al. Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC. Nat Commun. 3:865. doi: 10.1038/ncomms1859 (2012). |
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2013年12月24日(担当:中島) Gilkes DM et al. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proc Natl Acad Sci U S A. 2013 Dec 9 [EPub ahead of print] |
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2013年12月17日(担当:堤) Hubbi ME et al. Sirtuin-7 inhibits the activity of hypoxia-inducible factors. J Biol Chem. 288:20768-20775. 2013. |
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2013年12月10日(担当:片桐) Fallone F et al. ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression. Oncogene. 32:4387-4396. 2013. |
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2013年12月3日(担当:井上) Lin DC et al. PLK1 Is transcriptionally activated by NF-κB during cell detachment and enhances anoikis resistance through inhibiting β-catenin degradation in esophageal squamous cell carcinoma. Clin Cancer Res. 17:4285-4295. 2011. |
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2013年11月19日(担当:後藤) Hanna SC et al. HIF1α and HIF2α independently activate SRC to promote melanoma metastases. J Clin Invest. 123:2078-2093. 2013. |
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2013年11月12日(担当:小林) Faubert B et al. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab. 17:113-124. 2013. |
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2013年11月5日(担当:原田) Taniguchi CM et al. Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes. Nature Med. 19:1325-1330. 2013. |
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2013年10月29日(担当:鳥井) Harrison H et al. Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-α status. Cancer Res. 73:1420-1433. 2013. |
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2013年10月22日(担当:中島) Lim KS et al. Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner. Oncogene. 2013 Sep 30. [Epub ahead of print] |
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2013年10月15日(担当:子安) Lee K et al. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. PNAS. 106:2353-2358. 2009. |
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2013年10月8日(担当:堤) Cao Y et al. Tumor Cells Upregulate Normoxic HIF-1α in Response to Doxorubicin. Cancer Res. 73:6230-6242. 2013. |
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2013年10月1日(担当:片桐) Mak P et al. Estrogen receptor β sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription. PNAS. 110:4708-4713. 2013. |
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2013年9月10日(担当:井上) van Vuqt MA et al. A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol. 8:e1000287. 2010. |
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2013年9月3日(担当:後藤) Wu S et al. Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner. Cancer Res. 73:1787-1799. 2013. |
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2013年8月6日(担当:小林) Tannahill GM et al. Succinate is an inflammatory signal that induces IL-1β through HIF-1alpha. Nature. 496:238-242. 2013. |
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2013年7月30日(担当:原田) Yang C et al. Proteostasis modulators prolong missense VHL protein activity and halt tumor progression. Cell Rep. 3:52-59. 2013. |
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2013年7月23日(担当:子安) Spivak-Kroizman TR et al. Hypoxia Triggers Hedgehog-Mediated Tumor–Stromal Interactions in Pancreatic Cancer. Cancer Res. 73:3235-3247. 2013. |
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2013年7月16日(担当:中島) Gonzalez-Flores A et al. Interaction between PARP-1 and HIF-2α in the hypoxic response. Oncogene. 2013. Mar 4. [Epub ahead of print] |
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2013年7月9日(担当:堤) Sutendra G et al. Mitochondrial activation by inhibition of PDKII suppresses HIF1alpha signaling and angiogenesis in cancer. Oncogene. 32:1638-1650. 2013. |
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2013年7月2日(担当:片桐) Sun H et al. TRAF6 upregulates expression of HIF-1α and promotes tumor angiogenesis. Cancer Res. 2013 May 30. [Epub ahead of print] |
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2013年6月25日(担当:井上) Kasahara K et al. PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition. Nat Commun. 2013;4:1882. doi:10.1038/ncomms2879. |
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2013年6月18日(担当:後藤) Gilkes DM et al. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res. 73:3285-3296. 2013 |
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2013年6月11日(担当:小林) Vanharanta S et al. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat Med. 19:50-56. 2013. |
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2013年6月4日(担当:原田) Cooke VG et al. Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway. Cancer Cell. 21:66-81. 2012. |