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Oncogene. 38:1845-1859. 2019.
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Teng Y et al. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB.
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Nakada Y et al. Hypoxia induces heart regeneration in adult mice.
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Wang Y et al. Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odorevoked innate fear behaviors.
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Ge C et al. The histone demethylase KDM6B regulates temprature-dependent sex determination in a turtle species.
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Zhang J et al. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.
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Kim IJ et al. Helicobacter pylori infection modulates host cell metabolism through VacA-dependent inhibition of mTORC1.
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Wen J et al. Helicobactet pylori infection promotes Aquaporin 3 expression via the ROS-HIF-1alpha-AQP3-ROS loop in stomach mucosa: a potential novel mechanism for cancer pathogenesis.
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Olenchock BA et al. EGLN1 inhibition and rerouting of alpha-ketoglutarate suffice for remote ischemic protection.
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Arena G et al. Mitochondrial MDM2 regulates respiratory complec I activity independently of p53.
Mol Cell. 69:594-609. 2018.
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Raffel S et al. BCAT1 restricts alphaKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.
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Niu Y et al. MiRNA-646-mediated reciprocal repression between HIF-1alpha and MIIP contributes to tumorigenesis of pancreatic cancer.
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Man J et al. Hypoxic induction of Vasorin regulates Notch1 turnover to maintain glioma stem-like cells.
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Du W et al. HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism.
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Nagao A et al. Hydroxylation of a conserved tRNA modification establishes non-universal genetic code in echinoderm mitochondria..
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Wu D et al. Structural integration in hypoxia-inducible factors.
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Geller LT et al. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.
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Johansson E et al. CD44 interacts with HIF-2 alpha to modulate the hypoxic phenotype of perinecrotic and perivascular glioma cells.
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McGinn O et al. Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF-1 transcription complex in pancreatic cancer.
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Shih JW et al. Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1alpha co-activator driving oral cancer progression.
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Lin CW et al. Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1alpha/HDAC/Slug axis..
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Xu Y et al. Glycolysis determines dichotomous regulation of T cell subsets in hypoxia.
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Foskolou IP et al. Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication.
Mol Cell. 66:206-220. 2017.
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Nat Cell Biol. 19:530-541. 2017.
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Miroshnikova YA et al. Tissue mechanics promote IDH1-dependent HIF1alpha-tenascin C feedback to regulate glioblastoma aggression.
Nat Cell Biol. 18:1336-1345. 2016.
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Burr SP et al. Mitochondrial protein lipoylation and the 2-oxoglutarate dehydrogenase complex controls HIF1alpha stability in aerobic conditions.
Cell Metab. 25:740-752. 2016.
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Rezaeian AH et al. TRAF6-ATM-H2AX signaling axis promotes HIF-1alpha activation, tumorigenesis and metastasis.
Nat Cell Biol. 19:38-51. 2017.
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Samanta D et al. PHGDH expression is required for mitochondrial redox homeostasis, breast cancer stem cell maintenance, and lung metastasis..
Cancer Cell. 76:4430-4442. 2016.
2017年3月14日(担当:小林)
Lin A et al. The LINK-A linRNA activates normoxic HIF1alpha signaling in triple-negative breast cancer.
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Cell. 167:816-828. 2016.
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Lee G et al. Oxidative dimerization of PHD2 is responsible for its inactivation and contributes to metabolic reprogramming via HIF-1alpha activation.
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Briggs KJ et al. Paracrine induction of HIF by glutamate in breast cancer: RglN1 sense cysteine.
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Li TY et al. ULK1/2 constitute a bifurcate node controlling glucose metabolic fluxes addion to autophage.
Mol Cell. 62:359-370. 2016
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Lee SB et al. An ID2-dependent mechanism for VHL inactivation in cancer.
Nature. 529:172-177. 2016
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Jiang L et al. Reductive carboxylation supports redox homeostasis during anchorage-independent growth.
Nature. 532:255-258. 2016
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Thienpont B et al. Tumour hypoxia causes DNA hypermethylation by reducing TET activity.
Nature. 537:63-68. 2016
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Fischer KR et al. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance.
Nature. 527:472-476. 2015.
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Pan M et al. Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.
Nat Cell Biol. 18:1090-1101. 2016.
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Ashton TM et al. The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia.
Nat Commun. 7:12308. 2016.
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Guo J et al. pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.
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Kim Y et al. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis.
Nat Commun. 7:10347. 2016.
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Zhang H et al. HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells.
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Siegert I et al. Ferritin-mediated iron sequestration stabilizes hypoxia-inducible factor-1α upon LPS activation in the presence of ample oxygen.
Cell Rep. 13:2048-2055. 2015.
2016年1月5日(担当:堤)
Yang Jet al. Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer.
Proc Natl Acad Sci USA. 112:15172-15177. 2015.
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Dupuy F et al. PDK1-dependent metabolic reprogramming dictates metastatic potential in breast cancer.
Cell Metab. 22:577-589. 2015.
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Genes Dev. 29:2244-2257. 2015.
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Rupaimoole R et al. Hypoxia-mediated downregulation of miRNA biogenesis promotes tumor progression.
Nat Commun. 5:5202. 2015.
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Li Y et al. The STIM1 mediates hypoxia-driven hepatocarcinogenesis via interaction with HIF-1.
Cell Reports. 12:388-395. 2015.
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Rao X et al. O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth.
Nat Commun. 6:8468. 2015.
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Kuchnio A et al. The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts.
Cell Reports. 12:992-1005. 2015.
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Cell Metab. 22:304-311. 2015.
2015年9月1日(担当:中島)
Lu H et al. PChemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype..
Proc Natl Acad Sci USA. 112:E4600-4609. 2015.
2015年8月11日(担当:片桐)
MaK P et al. Prostate Tumorigenesis Induced by PTEN Deletion Involves Estrogen Receptor b Repression.
Cell Reports. 10:1982-1991. 2015.
2015年8月4日(担当:後藤)
Keskin D et al. Targeting Vascular Pericytes in Hypoxic Tumors Increases Lung Metastasis via Angiopoietin-2.
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Kimura W et al. Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart.
Nature. 523:226-230. 2015.
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LaGory EL et al. Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma.
Cell Rep. 12:116-127. 2015.
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Cox TR et al. The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase pathway.
Nature. 522:106-110. 2015.
2015年6月30日(担当:新谷)
Yu HP et al. TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway.
Sci Rep. 5:9853. 2015.
2015年6月23日(担当:鳥井)
Wang T et al. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.
Proc Natl Acad Sci USA. 111:E3234-E3242. 2014.
2015年6月16日(担当:中島)
El-Naggar AI et al. Translational Activation of HIF1a by YB-1 Promotes Sarcoma Metastasis.
Cancer Cell. 27:682-697. 2015.
2015年6月9日(担当:堤)
Ordonez-Navadijo A et al. Mutant versions of von Hippel-Lindau (VHL) can protect HIF1α from SART1-mediated degradation in clear-cell renal cell carcinoma.
Oncogene. in press.
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Finger EC et al. Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells.
Proc Natl Acad Sci USA. 112:4441-4446. 2015.
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Leszczynska KB et al. Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT.
J Clin Invest. 125:2385-2398. 2015.
2015年5月12日(担当:小林)
Kim D et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
Nature. 520:363-367. 2015.
2015年4月28日(担当:原田)
Lee DC et al. A Lactate-Induced Response to Hypoxia.
Cell. 161:1-15. 2015.
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Dulloo I et al. Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome.
Nat Cell Biol. 17:511-523. 2015.
2015年4月7日(担当:堤)
Gerez J et al. RSUME inhibits VHL and regulates its tumor suppressor function.
Oncogene. in press.
2015年3月31日(担当:片桐)
Palsson-McDermott EM et al. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
Cell Metab. 21:65-80. 2015.
2015年3月24日(担当:後藤)
Zhang D et al. Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3a Downregulation.
Cell Rep. 10:1335-1348. 2015.
2015年3月10日(担当:小林)
Ameri K et al. HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.
Cell Rep. 10: 891-899. 2015.
2015年2月24日(担当:原田)
TBA
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Henze AT et al. Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR
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2014年2月10日(担当:中島)
Stantic M et al. TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity.
Proc Natl Acad Sci U S A. 112:220-225. 2015.
2014年2月3日(担当:堤)
Singleton DC et al. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis.
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Ma B et al. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase.
Nat Cell Biol. 17: 95-103. 2014.
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Walter KM et al. Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy.
Cell Metab. 20:882-8972014.
2014年12月16日(担当:後藤)
Colegio OR et al. Functionalpolarization of tumour-associated macrophages by tumour-derived lactic acid.
Nature. 513:559-563. 2014.
2014年12月9日(担当:小林)
Choudhry H et al. Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.
Oncogene. 2014 Nov 24. doi: 10.1038/onc.2014.378. [Epub ahead of print]
2014年12月2日(担当:原田)
van den Beucken T et al. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.
Nat. Commun. 5:5203. 2014. doi: 10.1038/ncomms6203.
2014年11月18日(担当:鳥井)
Cheng SC et al. mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.
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2014年11月11日(担当:中島)
Fan Y et al. Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation.
Nat Cell Biol. 16:445-456. 2014.
2014年10月28日(担当:後藤)
Yan Met al. The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation.
J Clin Invest. 124:2640-2650.2014
2014年10月21日(担当:片桐)
Rankin EB et al. Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.
Proc Natl Acad Sci U S A. 111:13373-13378. 2014
2014年10月14日(担当:井上)
Srivastava N et al. Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels.
Cell Metab. 20:650-661. 2014.
2014年10月7日(担当:堤)
Li G et al. SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.
Cancer Cell. 25:455-468. 2014.
2014年9月16日(担当:小林)
Li B et al. Fructose-1,6-bisphosphatase opposes renal carcinoma progression.
Nature. 513:251-255. 2014.
2014年9月9日(担当:鳥井)
Villa JC et al. Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer.
Cell Rep. 8:1077-1092.2014.
2014年9月2日(担当:中島)
Hubbi MEet al. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to
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Proc Natl Acad Sci U S A. 111:E3325-E3334. 2014.
2014年8月19日(担当:堤)
Kilic Eren M et al. The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced Senescence.
PLoS One. 9:e101064. 2014.
2014年8月12日(担当:片桐)
Sinkevicius KW et al. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.
Proc Natl Acad Sci U S A. 111:10299-10304. 2014
2014年7月29日(担当:井上)
Ingolia NT et al. Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling.
Science. 324:218-223. 2009.
2014年7月22日(担当:後藤)
Chaturvedi P et al. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment.
Proc Natl Acad Sci U S A. 111:E2120-E2029. 2014.
2014年7月8日(担当:小林)
Norman MZ et al. PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation.
J Exp Med. 211:781-790. 2014
2014年7月1日(担当:鳥井)
Ramasamy SK et al. Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.
Nature. 507:376-380. 2014.
2014年6月24日(担当:中島)
Ferrer CM et al. O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway.
Mol Cell. 54:820-831. 2014.
2014年6月10日(担当:堤)
Taniguchi CM et al. PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2.
Sci Transl Med. 6(236): 236ra64. 2014.
2014年6月3日(担当:片桐)
Faubert B et al. Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.
Proc Natl Acad Sci U S A. 111:2554-2559. 2014.
2014年5月20日(担当:井上)
Ward A and Hudson JW. p53-Dependent and Cell Specific Epigenetic Regulation of the Polo-like kinases under Oxidative Stress.
PLoS One.9:e87918. 2014.
2014年5月13日(担当:後藤)
Finger EC et al. CTGF is a therapeutic target for metastatic melanoma.
Oncogene. 33:1093-1100. 2014.
2014年4月22日(担当:小林)
Joshi HP et al. Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis.
Proc Natl Acad Sci U S A.111:5331-5336. 2014.
2014年4月15日(担当:鳥井)
Spencer JA et al. Directmeasurementoflocaloxygenconcentrationin the bone marrow of live animals.
Nature. 508:269-273. 2014.
2014年4月1日(担当:中島)
Chen X et al. XBP1 promotes triple-negative breast cancer by controlling the HIF1a pathway.
Nature. 508:103-107. 2014.
2014年3月25日(担当:堤)
Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response.
Proc Natl Acad Sci U S A. 111:2560-2565. 2014.
2014年3月18日(担当:片桐)
Sun RC and Denko NC. Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth.
Cell Metab. 19:285-292. 2014.
2014年3月11日(担当:井上)
Xie CM et al. Cardiac glycosides block cancer growth through HIF-1α- and NF-κB-mediated Plk1.
Carcinogenesis. 34:1870-1880. 2013.
2014年2月25日(担当:後藤)
Wang HJ et al. JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.
Proc Natl Acad Sci U S A. 111:279-284. 2014.
2014年2月4日(担当:小林)
Barriga et al. The hypoxia factor Hif-1alpha controls neural crest chemotaxis and epithelial to mesenchymal transition.
J Cell Biol. 201:759-776. 2013.
2014年1月28日(担当:原田)
Yang et al. Reciprocal regulation of HIF-1alpha and LincRNA-p21 modulates the Warburg effect.
Molecular Cell. 53:88-100. 2014.
2014年1月21日(担当:鳥井)
Cowburn AS et al. HIF isoforms in the skin differentially regulate systemic arterial pressure.
Proc Natl Acad Sci U S A. 110:17570-17575. 2013.
2014年1月14日(担当:子安)
Blandino G et al. Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC.
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2013年12月24日(担当:中島)
Gilkes DM et al. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells.
Proc Natl Acad Sci U S A. 2013 Dec 9 [EPub ahead of print]
2013年12月17日(担当:堤)
Hubbi ME et al. Sirtuin-7 inhibits the activity of hypoxia-inducible factors.
J Biol Chem. 288:20768-20775. 2013.
2013年12月10日(担当:片桐)
Fallone F et al. ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression.
Oncogene. 32:4387-4396. 2013.
2013年12月3日(担当:井上)
Lin DC et al. PLK1 Is transcriptionally activated by NF-κB during cell detachment and enhances anoikis resistance through inhibiting β-catenin degradation in esophageal squamous cell carcinoma.
Clin Cancer Res. 17:4285-4295. 2011.
2013年11月19日(担当:後藤)
Hanna SC et al. HIF1α and HIF2α independently activate SRC to promote melanoma metastases.
J Clin Invest. 123:2078-2093. 2013.
2013年11月12日(担当:小林)
Faubert B et al. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo.
Cell Metab. 17:113-124. 2013.
2013年11月5日(担当:原田)
Taniguchi CM et al. Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes.
Nature Med. 19:1325-1330. 2013.
2013年10月29日(担当:鳥井)
Harrison H et al. Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-α status.
Cancer Res. 73:1420-1433. 2013.
2013年10月22日(担当:中島)
Lim KS et al. Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner.
Oncogene. 2013 Sep 30. [Epub ahead of print]
2013年10月15日(担当:子安)
Lee K et al. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells.
PNAS. 106:2353-2358. 2009.
2013年10月8日(担当:堤)
Cao Y et al. Tumor Cells Upregulate Normoxic HIF-1α in Response to Doxorubicin.
Cancer Res. 73:6230-6242. 2013.
2013年10月1日(担当:片桐)
Mak P et al. Estrogen receptor β sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription.
PNAS. 110:4708-4713. 2013.
2013年9月10日(担当:井上)
van Vuqt MA et al. A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.
PLoS Biol. 8:e1000287. 2010.
2013年9月3日(担当:後藤)
Wu S et al. Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner.
Cancer Res. 73:1787-1799. 2013.
2013年8月6日(担当:小林)
Tannahill GM et al. Succinate is an inflammatory signal that induces IL-1β through HIF-1alpha.
Nature. 496:238-242. 2013.
2013年7月30日(担当:原田)
Yang C et al. Proteostasis modulators prolong missense VHL protein activity and halt tumor progression.
Cell Rep. 3:52-59. 2013.
2013年7月23日(担当:子安)
Spivak-Kroizman TR et al. Hypoxia Triggers Hedgehog-Mediated Tumor–Stromal Interactions in Pancreatic Cancer.
Cancer Res. 73:3235-3247. 2013.
2013年7月16日(担当:中島)
Gonzalez-Flores A et al. Interaction between PARP-1 and HIF-2α in the hypoxic response.
Oncogene. 2013. Mar 4. [Epub ahead of print]
2013年7月9日(担当:堤)
Sutendra G et al. Mitochondrial activation by inhibition of PDKII suppresses HIF1alpha signaling and angiogenesis in cancer.
Oncogene. 32:1638-1650. 2013.
2013年7月2日(担当:片桐)
Sun H et al. TRAF6 upregulates expression of HIF-1α and promotes tumor angiogenesis.
Cancer Res. 2013 May 30. [Epub ahead of print]
2013年6月25日(担当:井上)
Kasahara K et al. PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition.
Nat Commun. 2013;4:1882. doi:10.1038/ncomms2879.
2013年6月18日(担当:後藤)
Gilkes DM et al. Collagen prolyl hydroxylases are essential for breast cancer metastasis.
Cancer Res. 73:3285-3296. 2013
2013年6月11日(担当:小林)
Vanharanta S et al. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.
Nat Med. 19:50-56. 2013.
2013年6月4日(担当:原田)
Cooke VG et al. Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway.
Cancer Cell. 21:66-81. 2012.